Cranberry offers numerous cardiovascular benefits. According to several studies, this fruit promotes the oxidation of low-density lipoprotein, enhances high-density lipoprotein, reduces platelet coagulation, and improves vascular activity. Albino male rats were divided into five groups (n = 5 per group). The control group received intraperitoneal administration of normal saline. The second group was injected with metaproterenol (MET) 3 days a week for 4 weeks. The third, fourth, and fifth groups were given cranberry extract in doses of 75, 100, and 150, respectively, along with heart-damaging drugs. Blood samples were collected and sent to the laboratory on the fourth weekend and 1 week after completing the injections in the fourth week (the sixth weekend) for analyzing serum factors such as cardiac creatine kinase MB, cardiac troponin I (cTnI), and aspartate aminotransferase (AST). The serum activity of the cardiac evaluation parameters in the fourth week demonstrated a highly significant correlation among the groups with respect to AST and cTnI (p < .001). Additionally, a significant relationship was observed between AST and cTnI within the target groups (p < .05). Ultimately, the findings indicated that the consumption of cranberry extract, due to its impact on heart function, could effectively modify serum indicators associated with heart damage. The utilized extract also exhibited efficacy, albeit with variable effects. Therefore, it is recommended to use cranberry extract synergistically with other chemical and herbal medications to achieve more sustained effects.

Background: Among the several types of periodontitis, chronic periodontitis is the utmost common form of periodontal disease which can progress with a slow rate but may have a sudden rapid rate of progression along with a remarkable bone loss. In terms of adequacy in sufficient periodontal regeneration, periodontal flap surgeries lack the potential and takes often a back seat. Several other regenerative methods have been promoted among which platelet rich fibrin (PRF) is seen to be most extensively used. It is an old and successful trend to either add PRF or to infuse it along with other drugs at the wound site to enhance periodontal regeneration. Several herbal products were used as an infusion with PRF in the past for the antimicrobial effect but no herbal products were used in the form of a synergetic agent with PRF for enhancing periodontal regeneration. Cranberry fruit, its origin is from North America has been much popular because of its essential ingredients for a good health. It has got a significant therapeutic potential as an antimicrobial agent and as an antioxidant agent but been never used for enhancing periodontal regeneration. Hence, the current study's goal is to assess and compare the synergetic effect of Cranberry extract with PRF versus the use of PRF alone in the treatment of chronic periodontitis. 

Materials and Method: A double blinded randomized clinical trial (RCT) was done with twenty subjects which included patients based on the selection criteria in the age group of 35 to 55 years having periodontal intrabony defects. The Control Group A received PRF alone and the Test Group B received PRF+CRN at the site of intrabony defects. Subjects in each group were assessed for their clinical parameters such as probing pocket depth (PPD), relative attachment level (RAL), gingival index (GI), plaque index (PI) and radiographical parameters such as defect depth (DD), defect area (DA) and defect fill % (DF %) at baseline. The follow up period was decided according to the previous studies at three, six and nine months respectively. 

Results: There was a statistically significant enhancement in the clinical and radiographic parameters from baseline to three, six and nine months in each group. However, the treated group showed statistically significant than the control group. 

Conclusion: Within the limitations of the given study, use of PRF+CRN was efficacious in comparison to the use of PRF alone in the treatment of intrabony defect.

Cranberry (poly)phenols may have potential health benefits. Circulating (poly)phenol metabolites can act as mediators of these effects, but they are subjected to an extensive inter-individual variability. This study aimed to quantify both plasma and urine (poly)phenol metabolites following a 12-week intake of a cranberry powder in healthy older adults, and to investigate inter-individual differences by considering the existence of urinary metabotypes related to dietary (poly)phenols. Up to 13 and 67 metabolites were quantified in plasma and urine respectively. Cranberry consumption led to changes in plasma metabolites, mainly hydroxycinnamates and hippuric acid. Individual variability in urinary metabolites was assessed using different data sets and a combination of statistical models. Three phenolic metabotypes were identified, colonic metabolism being the main driver for subject clustering. Metabotypes were characterized by quali-quantitative differences in the excretion of some metabolites such as phenyl-y-valerolactones, hydroxycinnamic acids, and phenylpropanoic acids. Metabotypes were further confirmed when applying a model only focused on flavan-3-ol colonic metabolites. 5-(3',4'- dihydroxyphenyl)-y-valerolactone derivatives were the most relevant metabolites for metabotyping. Metabotype allocation was well preserved after 12-week intervention. This metabotyping approach for cranberry metabolites represents an innovative step to handle the complexity of (poly)phenol metabolism in free-living conditions, deciphering the existence of metabotypes derived from the simultaneous consumption of different classes of (poly)phenols. These results will help contribute to studying the health effects of cranberries and other (poly) phenol-rich foods, mainly considering gut microbiota-driven individual differences.

The Vaccinium L. (Ericaceae) genus consists of a globally widespread and diverse genus of around 4250 species, of which the most valuable is the Vaccinioidae subfamily. The current review focuses on the distribution, history, bioactive compounds, and health-related effects of three species: cranberry, blueberry, and huckleberry. Several studies highlight that the consumption of Vaccinium spp. presents numerous beneficial health-related outcomes, including antioxidant, antimicrobial, anti-inflammatory, and protective effects against diabetes, obesity, cancer, neurodegenerative diseases and cardiovascular disorders. These plants' prevalence and commercial value have enhanced in the past several years; thus, the generated by-products have also increased. Consequently, the identified phenolic compounds found in the discarded leaves of these plants are also presented, and their impact on health and economic value is discussed. The main bioactive compounds identified in this genus belong to anthocyanins (cyanidin, malvidin, and delphinidin), flavonoids (quercetin, isoquercetin, and astragalin), phenolic acids (gallic, p-Coumaric, cinnamic, syringic, ferulic, and caffeic acids), and iridoids.