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Lingonberry, cranberry and blackcurrant juices affect mRNA

Kivimaki AS, Ehlers PI, Siltari A, Turpeinen AM,
J Funct Food 4;496-503

Flavonoids and other phenolic compounds affect low-grade inflammation related to cardiovascular diseases among other positive health effects. Cardioprotective actions are
mainly due to enhanced endothelial function and production of nitric oxide (NO).We investigated vascular anti-inflammatory effects of cranberry (Vaccinium oxycoccos), lingonberry (Vaccinium vitis-idaea) and blackcurrant (Ribes nigrum) juices given as drinking fluid ad
libitum to spontaneously hypertensive rats (SHR), a widely used model of human hypertension, in an 8 week ntervention study. The animals were sacrificed, the aortas cleaned and RNA was extracted. cDNA was prepared for real-time PCR and blood was collected for biochemical
analyses. The mRNA expressions of angiotensin-converting enzyme 1 (ACE1), cyclooxygenase 2 (COX2), monocyte chemoattractant protein 1 (MCP1) and P-selectin were
significantly reduced in the cranberry and lingonberry groups. These findings suggest that cranberry and lingonberry cold-compressed juices have anti-inflammatory and antiatherothrombotic actions in long-term treatment of SHR.